货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T28117-1ml	10mM in DMSO	￥200.00 T28117-1ml ￥200.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T28117-1ml

10mM in DMSO

￥200.00

货期：3-5天

产品描述：

COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders

靶点：

AMPK

体外研究：

COH-SR4 (1-5 μM; 24 hours) results in a dose-dependent increase in the phosphorylation of AMPK and its substrate ACC in 3T3-L1 preadipocytes, as well as in cancer cells such as HL-60, HeLa, MCF-7.

COH-SR4 (3-5 µM; 7 days) significantly inhibits 3T3-L1 adipocyte differentiation in a dose-dependent manner.

COH-SR4 (1-5 μM; 24 hours) promotes cell G1 cycle arrest.

COH-SR4 significantly reduces intracellular lipid accumulation and downregulates the expression of key adipogenesis-related transcription factors and lipogenic proteins.

体内研究：

COH-SR4 (5 mg/kg; i.g.; 3x/week; for 6 weeks) reduces body weight and fat mass in high fat diet (HFD) obese mice without affecting food intake.

COH-SR4 improves glycemic control and dyslipidemia in HFD obese mice.

COH-SR4 decreases adipose tissue hypertrophy and affects circulating adipokine levels in HFD obese mice.

COH-SR4 prevents hepatic lipid accumulation and fatty liver in HFD obese mice. Animal Model: Nine-week old male C57BL/6J mice Dosage: 5 mg/kg Administration: Oral gavage, three times a week, for 6 weeks Result: Decreased body weight and fat mass in HFD obese mice.

参考文献：

1. James L Figarola, et al. Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation. Int J Mol Med. 2013 May;31(5):1166-76.

2. James Lester Figarola, et al. COH-SR4 Reduces Body Weight, Improves Glycemic Control and Prevents Hepatic Steatosis in High Fat Diet-Induced Obese Mice. PLoS One. 2013; 8(12): e83801.

溶解性：

Soluble in DMSO

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.857 ml	14.284 ml	28.569 ml
5 mM	0.571 ml	2.857 ml	5.714 ml
10 mM	0.286 ml	1.428 ml	2.857 ml
50 mM	0.057 ml	0.286 ml	0.571 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

质检证书(COA)

输入产品批号：

如何获取质检证书(COA)?

请输入货号和一个与之匹配的批号。
例如:
批号：JS298415 货号：S20001-25g
在货品标签上如何找到货号和批号?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置