(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
靶点:
Glucokinase
参考文献:
1. Zhang Y, Wang X, Li X, et al. Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae[J]. Antimicrobial agents and chemotherapy. 2019, 63(7): e00271-19. 2. Clem B, et al. Mol Y Ther. 2008 Jan;7(1):110-20.