| 产品描述： | ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders |
| 靶点： |
IC50: 0.31 μM (Kir7.1) |
| 体外研究： |
ML418 has inhibitory activity for Kir7.1 dose-dependently with an IC50 value of 0.31 μM. ML418 has selectivity for Kir7.1 and Kir6.2/SUR1 with IC50 values of 1.3 μM and 1.9 μM, respectively |
| 体内研究： |
ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution. Animal Model: Rats and Mice Dosage: 30 mg/kg Administration: Intraperitoneal Result: Showed a suitable PK profile (Cmax = 0.20 μM and Tmax = 3 h), excellent CNS penetration with a mouse brain: Kp of 10.9, brain (323.9 ng/g): plasma (29.5 ng/mL). |
| 参考文献： |
1. ML418, et al. ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.646 ml |
13.232 ml |
26.464 ml |
| 5 mM |
0.529 ml |
2.646 ml |
5.293 ml |
| 10 mM |
0.265 ml |
1.323 ml |
2.646 ml |
| 50 mM |
0.053 ml |
0.265 ml |
0.529 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京