DLinDMA, a ionizable cationic lipid, is a key lipid component of stable nucleic acid lipid particles (SNALPs) as a benchmark. DLinDMA is used for siRNA delivery
靶点:
Liposome
体外研究:
The structure of DLinDMA can be divided into three main regions: the hydrocarbon chains, the linker and the headgroup
体内研究:
DLinDMA has virtually indistinguishable blood pharmacokinetic profiles in mice
参考文献:
1. Semple SC, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010 Feb;28(2):172-6.