货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T28249-1ml	10mM in DMSO	￥300.00 T28249-1ml ￥300.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T28249-1ml

10mM in DMSO

￥300.00

货期：3-5天

体外研究：

AA147 (20-0.078 μM (dilution in half); 6 or 16 h) protects against glutamate-induced oxidative toxicity in HT22 cells by decreasing the reactive oxygen species (ROS)-associated damage.

AA147 (10 μM; 16 h) induces NRF2-dependent upregulation of oxidative stress response genes in HT22 cells.

AA147 (10 μM; 16 h) covalently modifies KEAP1 to promote NRF2 activation in HT22 cells.

AA147 (5, 10, 15 μM; 4, 8, 16, 24, 48 h) induces ATF6 activation and upregulates phosphorylation of cofilin in BPAEC.

AA147 (10 μM; 24 h) reduces LPS-induced endothelial barrier disruption in BPAEC.

AA147 (5, 10 μM; 135 h) enhances lung endothelial barrier integrity.

体内研究：

AA147 (intrathecal injection; single for 3 days) can rebalance XBP1s expression in severe SMA-like mice by activating ATF6, and also induce survival motor neuron expression and spinal motorneuron protection.

参考文献：

1. Rosarda JD, et al. Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. ACS Chem Biol. 2021 Dec 17;16(12):2852-2863.

2. Kubra KT, et al. Activating transcription factor 6 protects against endothelial barrier dysfunction. Cell Signal. 2022 Aug 4;99:110432.

3. D'Amico D, et al. Activating ATF6 in spinal muscular atrophy promotes SMN expression and motor neuron survival through the IRE1α-XBP1 pathway. Neuropathol Appl Neurobiol. 2022 Aug;48(5):e12816.

4. Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.

溶解性：

DMSO : 50 mg/mL (195.84 mM; Need ultrasonic)

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.917 ml	19.584 ml	39.168 ml
5 mM	0.783 ml	3.917 ml	7.834 ml
10 mM	0.392 ml	1.958 ml	3.917 ml
50 mM	0.078 ml	0.392 ml	0.783 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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