| 产品描述： | FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties |
| 靶点： |
Somatostatin release |
| 体内研究： |
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease. Animal Model: Male Lister Hooded rats, weighing approximately 270-300 Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration: Administered i.p. Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition. |
| 参考文献： |
1. Tokita K, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005 Dec 19;527(1-3):111-20. 2. McCarthy AD, et al. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacol Biochem Behav. 2011 Mar;98(1):76-80 |
| 溶解性： |
Soluble in DMSO、H2O |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.784 ml |
18.918 ml |
37.836 ml |
| 5 mM |
0.757 ml |
3.784 ml |
7.567 ml |
| 10 mM |
0.378 ml |
1.892 ml |
3.784 ml |
| 50 mM |
0.076 ml |
0.378 ml |
0.757 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京