| 产品描述： | OUL35 (NSC39047) is a potent and selective inhibitor of ARTD10 (PARP-10), with an IC50 of 329 nM |
| 靶点： |
ARTD10/PARP10:329 nM (IC50) |
| 体外研究： |
OUL35 rescues HeLa cells from ARTD10-induced cell death and sensitizes cells to DNA damage. OUL35 (3 μM) binds to endogenous ARTD10 in U2OS cells. OUL35 also inhibits ARTD8 (23.4 μM), ARTD4 (22.6 μM), and ARTD15 (4.17 μM) but with modest potency. OUL35 makes hydrogen bonds to the amide and carbonyl of Gly888 and to the side-chain hydroxyl of Ser927. OUL35 stacks between Tyr919 and Tyr932, like 3AB in the crystal structure |
| 参考文献： |
1. Harikanth Venkannagari, et al. Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage. Cell Chem Biol. 2016 Oct 20;23(10):1251-1260. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.902 ml |
19.508 ml |
39.017 ml |
| 5 mM |
0.78 ml |
3.902 ml |
7.803 ml |
| 10 mM |
0.39 ml |
1.951 ml |
3.902 ml |
| 50 mM |
0.078 ml |
0.39 ml |
0.78 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京