| 产品描述： | YH-306 is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis |
| 靶点： |
Src; Rho; FAK; MMP; MMP; PI3K |
| 体外研究： |
YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1, and the expression of MMP2 and MMP9. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 inhibits Arp2/3 complex-mediated actin polymerization |
| 参考文献： |
1. Dai F, Chen Y, Huang L, Wang J, Zhang T, Li J, Tong W, Liu M, Yi Z. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19(2):383-95. doi: 10.1111/jcmm.12450. Epub 2014 Oct 29. PubMed PMID: 25351103; PubMed Central PMCID: PMC4407606. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.264 ml |
16.321 ml |
32.641 ml |
| 5 mM |
0.653 ml |
3.264 ml |
6.528 ml |
| 10 mM |
0.326 ml |
1.632 ml |
3.264 ml |
| 50 mM |
0.065 ml |
0.326 ml |
0.653 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
