| 产品描述： | Pyridoxal isonicotinoyl hydrazine is a cell-permeable and relatively non-toxic iron (Fe3+) chelator that shows high iron chelation efficacy both in vitro and in vivo |
| 体内研究： |
Intraperitoneal administration of PIH to mice (5 mg/25 gm mouse/day) over 6 days decreased 59Fe levels in the liver, spleen, and kidney but not in the blood. After oral administration, PIH resulted in an eightfold increase in fecal Fe excretion and possibly some urinary excretion of Fe |
| 参考文献： |
1. 1. Richardson DR, et al. Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. J Lab Clin Med. 1998 Apr;131(4):306-15. 2. Brewer CT, et al. The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis. Toxicol Sci. 2019 Mar 1;168(1):209-224. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.493 ml |
17.465 ml |
34.93 ml |
| 5 mM |
0.699 ml |
3.493 ml |
6.986 ml |
| 10 mM |
0.349 ml |
1.747 ml |
3.493 ml |
| 50 mM |
0.07 ml |
0.349 ml |
0.699 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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危险品化学品经营许可证（不带存储）
营业执照(三证合一)
