| 产品描述： | Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription |
| 靶点： |
TET1:33 μM (IC50);TET2:73 μM (IC50) |
| 体外研究： |
Bobcat339 (10 μM; 24 hours) significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells |
| 参考文献： |
1. Chua GNL, et, al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31; 10(2): 180-185. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.359 ml |
16.793 ml |
33.586 ml |
| 5 mM |
0.672 ml |
3.359 ml |
6.717 ml |
| 10 mM |
0.336 ml |
1.679 ml |
3.359 ml |
| 50 mM |
0.067 ml |
0.336 ml |
0.672 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京