| 产品描述： | D159687 is a selective PDE4D inhibitor |
| 靶点： |
PDE4D |
| 体外研究： |
D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM. Western Blot Analysis Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 1 μM Incubation Time: 0, 1, 3, 6, 12, 24 hours Result: Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. Western Blot Analysis Cell Line: HT-22 (mouse hippocampal cell line) Concentration: 0.01 μM, 0.1 μM, 1 μM Incubation Time: 6 hours Result: CREB phosphorylation was optimal at 1 μM. |
| 体内研究： |
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques. Animal Model: Female Cynomolgus macaques (4–6 year old) Dosage: 0.05, 0.5, 5 mg/kg Administration: Oral daily for a week Result: A potential recruitment or enhancement of synaptic function with increased task difficulty. |
| 参考文献： |
1. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.726 ml |
13.63 ml |
27.26 ml |
| 5 mM |
0.545 ml |
2.726 ml |
5.452 ml |
| 10 mM |
0.273 ml |
1.363 ml |
2.726 ml |
| 50 mM |
0.055 ml |
0.273 ml |
0.545 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京