| 产品描述: | L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS |
| 靶点: |
IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase) |
| 体内研究: |
L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice |
| 参考文献: |
1. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634. 2. Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635. 3. Moore WM, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8. |
| 溶解性: |
Soluble in H2O |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
5.341 ml |
26.704 ml |
53.407 ml |
| 5 mM |
1.068 ml |
5.341 ml |
10.681 ml |
| 10 mM |
0.534 ml |
2.67 ml |
5.341 ml |
| 50 mM |
0.107 ml |
0.534 ml |
1.068 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |