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Auten-99 HBr

    
10mM in DMSO

AUTEN-99

源叶(MedMol)
T28489 一键复制产品信息
1049780-58-6
C17H15BrN2S
359.29
Auten-99; Auten 99; Auten99; Auten-99 hydrochloride. Auten-99 HBr
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
T28489-1ml
10mM in DMSO

¥430.00

货期:3-5天 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述: Auten-99 HBr is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson’s and Huntington’s diseases. Furthermore, the molecule increases the survival of isolated neurons under normal and oxidative stress-induced conditions. Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthy aging.
靶点: Phosphatase
参考文献: 1. Kovács T, Billes V, Komlós M, Hotzi B, Manzéger A, Tarnóci A, Papp D, Szikszai F, Szinyákovics J, Rácz Á, Noszál B, Veszelka S, Walter FR, Deli MA, Hackler L Jr, Alfoldi R, Huzian O, Puskas LG, Liliom H, Tárnok K, Schlett K, Borsy A, Welker E, Kovács AL, Pádár Z, Erdős A, Legradi A, Bjelik A, Gulya K, Gulyás B, Vellai T. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014. doi: 10.1038/srep42014. PubMed PMID: 28205624; PubMed Central PMCID: PMC5311965. 2. Erdos Attila, Vellai Tibor. Compounds For Enhancing Autophagy.WO/2018/130863
溶解性: Soluble  in  DMSO
保存条件: -80℃(运输条件:冰袋低温运输)
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.783 ml 13.916 ml 27.833 ml
5 mM 0.557 ml 2.783 ml 5.567 ml
10 mM 0.278 ml 1.392 ml 2.783 ml
50 mM 0.056 ml 0.278 ml 0.557 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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