| 产品描述： | CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively |
| 靶点： |
IC50: 5 nM (Pim-1), 25 nM (Pim-2), 16 nM (Pim-3) |
| 体内研究： |
CX-6258 (50-100 mg/kg; p.o; daily; over a period of 21 days) exhibits robust in vivo efficacy in two Pim kinases driven tumor models |
| 参考文献： |
1. Mustapha Haddach, Jerome Michaux, Michael K, Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor. ACS Med. Chem. Lett., 2012, 3 (2), pp 135-139 2. Padmanabhan A, Gosc EB, Bieberich CJ. Stabilization of the prostate-specific tumor suppressor NKX3.1 by the oncogenic protein kinase Pim-1 in prostate cancer cells. J Cell Biochem. 2013 May;114(5):1050-7. |
| 溶解性： |
DMSO : ≥ 50 mg/mL (108.24 mM) |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.165 ml |
10.824 ml |
21.648 ml |
| 5 mM |
0.433 ml |
2.165 ml |
4.33 ml |
| 10 mM |
0.216 ml |
1.082 ml |
2.165 ml |
| 50 mM |
0.043 ml |
0.216 ml |
0.433 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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危险品化学品经营许可证（不带存储）
营业执照(三证合一)
