| 产品描述： | DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03 |
| 靶点： |
pKa: 5.03 (DHODH) |
| 体外研究： |
Designed a compound structurally related to Leflunomide, containing the furazan ring (Compound 14a), is designed. Compound 14a undergo ring 4 scission under physiological pH conditions to afford the corresponding cyano-oximes DHODH-IN-11 (Compound 14b). DHODH-IN-14 has been assayed as a DHODH inhibitor; its low potency is probably due to the unfavourable stereochemistry of the oxime substructure. |
| 参考文献： |
1. Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 备注： |
DHODH-IN-11 (Compound 14b) 是一种 Leflunomide 衍生物，也是一种二氢乳清酸脱氢酶 (DHODH) 的弱抑制剂，其 pKa 为 5.03。 |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.77 ml |
18.849 ml |
37.697 ml |
| 5 mM |
0.754 ml |
3.77 ml |
7.539 ml |
| 10 mM |
0.377 ml |
1.885 ml |
3.77 ml |
| 50 mM |
0.075 ml |
0.377 ml |
0.754 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京