货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T28670-1ml	10mM in DMSO	￥590.00 T28670-1ml ￥590.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T28670-1ml

10mM in DMSO

￥590.00

货期：3-5天

产品描述：

PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility

靶点：

5-HT6 Receptor:4-8 nM (Ki);5-HT6 Receptor:19 nM (IC50);5-HT1A Receptor:420 nM (Ki);5-HT1B Receptor:260 nM (Ki);5-HT1D Receptor:2.8 μM (Ki);5-HT2A Receptor:2.5 μM (IC50);5-HT2B Receptor:2.5 μM (IC50);5-HT2C Receptor:3.7 μM (IC50);Dopamine D3 Receptor:71 nM (Ki);Histamine H2 Receptor:0.64 μM (Ki);Opioid μ Receptor:0.45 μM (Ki)

体外研究：

PRX-07034 is both a potent and highly selective 5-HT6 receptor antagonist (≥100-fold selectivity for the 5-HT6 receptor compared to 68 other GPCRs, ion channels, and transporters. PRX-07034 inhibits 5-HT1A, 5-HT1B, 5-HT1D, Dopamine D3, Histamine H2, and Opioid μ receptor with Kis of 420 nM, 260 nM, 2.8 µM, 71 nM, 0.64 µM, and 0.45 µM, respectively. PRX-07034 inhibits 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50s of 2.5 µM, 2.5 µM, and 3.7 µM, respectively.
In functional assays, PRX-07034 demonstrates low antagonist activity for the dopamine D3 receptor (IC50=4.8 µM) and very low agonistic activity for the opioid μ-receptor (EC50=19 µM) .

体内研究：

PRX-07034 (0.1, 1, or 3 mg/kg; i.p.; 30 min prior to delayed spontaneous alternation testing) selectively enhances a switch to a place discrimination. Animal Model: Male Long-Evans rats weighing approximately 350 g Dosage: 0.1, 1, or 3 mg/kg Administration: Injected intraperitoneal Result: 1 and 3 mg/kg (but not 0.1 mg/kg) significantly enhanced delayed spontaneous alternation. The drug at 1 and 3 mg/kg also enhanced switching between a place and response strategy, but did not affect initial learning of either a place or response discrimination.

参考文献：

1. Eric G Mohler, et al. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 Apr;220(4):687-96.

溶解性：

Soluble in DMSO、H2O

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.044 ml	10.222 ml	20.445 ml
5 mM	0.409 ml	2.044 ml	4.089 ml
10 mM	0.204 ml	1.022 ml	2.044 ml
50 mM	0.041 ml	0.204 ml	0.409 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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PRX-07034 HCl

N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline hydrochloride

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)