| 产品描述: | T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase |
| 靶点: |
DNA/RNA Synthesis |
| 体外研究: |
T2AA(15 μM, 72 h) 抑制链间 DNA 交联(ICL)修复,它可以阻止作为 ICL 修复中间体形成的 DNA 双链断裂(DSB)的分解,具有抑制 DSB 修复的能力 |
| 参考文献: |
1. Akira Inoue, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014 Mar 7;289(10):7109-7120. |
| 溶解性: |
soluble in DMSO |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
1.957 ml |
9.783 ml |
19.566 ml |
| 5 mM |
0.391 ml |
1.957 ml |
3.913 ml |
| 10 mM |
0.196 ml |
0.978 ml |
1.957 ml |
| 50 mM |
0.039 ml |
0.196 ml |
0.391 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |