| 产品描述： | TM38837 is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist. TM38837 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effects. TM38837 reduces propensity for psychiatric side effects |
| 靶点： |
CB1 |
| 体外研究： |
TM38837 (10-100 mg/kg; p.o.) induces a significant increase in freezing behavior at 100 mg/kg. Animal Model: 7-8 weeks old male C57BL/6 N mice (B6N) Dosage: 10, 30, or 100 mg/kg Administration: p.o. Result: High dose (100 mg/kg) induced a significant increase in freezing behavior. |
| 体内研究： |
TM38837 (10-100 mg/kg；口服) 在 100 mg/kg 剂量下会诱导冷冻行为的显著增加。 |
| 参考文献： |
1. Micale V, et al. The Cannabinoid CB1 Antagonist TM38837 With Limited Penetrance to the Brain Shows ReducedFear-Promoting Effects in Mice. Front Pharmacol. 2019 Mar 20;10:207. 2. Klumpers LE, et al. Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects. Br J Clin Pharmacol. 2013 Dec;76(6):846-57. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.619 ml |
8.097 ml |
16.194 ml |
| 5 mM |
0.324 ml |
1.619 ml |
3.239 ml |
| 10 mM |
0.162 ml |
0.81 ml |
1.619 ml |
| 50 mM |
0.032 ml |
0.162 ml |
0.324 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京