| 产品描述： | Adaphostin is a p210Bcr/Abl tyrosine kinase inhibitor with IC50 of 14 μM. |
| 靶点： |
p210Bcr/Abl:14 μM |
| 体外研究： |
It also induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro |
| 体内研究： |
Adaphostin can damage both myeloid and lymphoid leukemia cells |
| 参考文献： |
1. Svingen PA, et al. Effects of the bcr/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro. Clin Cancer Res. 2000;6(1):237-249. 2. Chandra J, et al. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood. 2003;102(13):4512-4519. 3. Orsolic N, et al. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer Sci. 2006;97(9):952-960. |
| 溶解性： |
Soluble in DMSO、Ethanol |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.541 ml |
12.707 ml |
25.414 ml |
| 5 mM |
0.508 ml |
2.541 ml |
5.083 ml |
| 10 mM |
0.254 ml |
1.271 ml |
2.541 ml |
| 50 mM |
0.051 ml |
0.254 ml |
0.508 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
