| 产品描述： | SN-011 (GUN35901) 是 STING 特异性拮抗剂，IC50 为 76 nM。 |
| 靶点： |
STING:76 nM |
| 体内研究： |
Serum antinuclear antibody is markedly reduced by SN-011 treatment. SN-011 also significantly reduces the number of activated CD69+ CD8 T cells and memory CD44high CD62Llow CD4 and CD8 T cells to near normal levels in the spleens of treated Trex1−/− mice. SN-011 strongly reduces inflammation and protects Trex1−/− mice from death. |
| 细胞实验： |
Cell lines: HFFs Concentrations: 1 μM - 10 μM Incubation Time: 24 h Method: HFFs are harvested and lysed in lysis buffer with brief sonication. Cell lysate is collected and incubated with biotin (5 μM). For purified recombinant STING-CTD protein, 0.05 mg protein in 400 μL buffer (25 mM Tris-HCl, pH 7.5, 150 mM NaCl) was incubated with biotin (5 μM) for 1 h at 4 °C. Then the protein of interest was pull-down by streptavidinconjugated agarose and detected by immunoblot analysis. |
| 动物实验： |
Animal Models: Trex1−/− mice Dosages: 5 mg/kg, 10 mg/kg Administration: i.p. |
| 参考文献： |
1. Ze Hong, et al. Proc Natl Acad Sci U S A . 2021 Jun 15;118(24):e2105465118. |
| 溶解性： |
Soluble in DMSO、Ethanol |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.162 ml |
10.811 ml |
21.622 ml |
| 5 mM |
0.432 ml |
2.162 ml |
4.324 ml |
| 10 mM |
0.216 ml |
1.081 ml |
2.162 ml |
| 50 mM |
0.043 ml |
0.216 ml |
0.432 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京