| 产品描述： | FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist |
| 靶点： |
FPR1, FPR2/ALX |
| 体外研究： |
FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells. FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM). FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells. Cell Viability Assay Cell Line: Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors Concentration: 10-5, 10-3, 0.1, 10, 1000, 105, 107 nM Incubation Time: Result: Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC50 =11.6±1.9 nM). |
| 参考文献： |
1. Planagumà A, et al. Lack of activity of 15-epi-lipoxin A₄ on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function. Clin Exp Immunol. 2013 Aug;173(2):298-309. 2. Forsman H, et al. What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? Scand J Immunol. 2011 Sep;74(3):227-234. |
| 溶解性： |
soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.598 ml |
12.992 ml |
25.984 ml |
| 5 mM |
0.52 ml |
2.598 ml |
5.197 ml |
| 10 mM |
0.26 ml |
1.299 ml |
2.598 ml |
| 50 mM |
0.052 ml |
0.26 ml |
0.52 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京