| 产品描述： | VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer |
| 靶点： |
IC50: 8.9 μM (Myc-Max) |
| 体外研究： |
VPC-70063 (25 μM; 96 h) shows Myc-Max transcriptional activity inhibition of 106% and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 (6.25-25 μM, 48 h) causes apoptosis of LNCaP cells as indicated by cleavage of PARP. VPC-70063 (0-500 μM; 0-600 s) disrupts the interaction of Myc-Max with DNA in a dose dependent manner. Western Blot Analysis Cell Line: LNCaP cells Concentration: 6.25 μM, 12.5 μM and 25 μM Incubation Time: 48 h Result: Induced PARP cleavage. |
| 参考文献： |
1. Carabet LA, et al. Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer. Eur J Med Chem. 2018 Dec 5;160:108-119. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.643 ml |
13.216 ml |
26.432 ml |
| 5 mM |
0.529 ml |
2.643 ml |
5.286 ml |
| 10 mM |
0.264 ml |
1.322 ml |
2.643 ml |
| 50 mM |
0.053 ml |
0.264 ml |
0.529 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京