| 产品描述： | BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function |
| 体外研究： |
BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines. BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines. BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells. Western Blot Analysis Cell Line: MG87RET cell lines Concentration: 50 μM Incubation Time: 1, 5, 15, 45, 90 minutes Result: Activated AKT and ERK1/2 in time-dependently. |
| 参考文献： |
1. Leo Jakman, Characterization of small-molecule GDNF mimics. 2. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.568 ml |
7.841 ml |
15.683 ml |
| 5 mM |
0.314 ml |
1.568 ml |
3.137 ml |
| 10 mM |
0.157 ml |
0.784 ml |
1.568 ml |
| 50 mM |
0.031 ml |
0.157 ml |
0.314 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京