货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T29074-1ml	10mM in DMSO	￥960.00 T29074-1ml ￥960.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T29074-1ml

10mM in DMSO

￥960.00

货期：3-5天

产品描述：

PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50= 7.5 μM). Anti-tumor activies

靶点：

PRMT5

体外研究：

PR5-LL-CM01 has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1, and a range of IC50 at 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 has higher efficacy to specifically inhibit cancer cells and demonstrated low toxicity in normal cells. PR5-LL-CM01 strongly inhibited colony forming ability in both PANC1 and HT29 cells.
PR5-LL-CM01 inhibits NF-κB activation and its target gene expression in PDAC and CRC cells.
PR5-LL-CM01 (0-15 μM) dramatically decreases TNFα and IL8 expression in both PANC1 and HT29 cells.

体内研究：

PR5-LL-CM01 (20mg/kg; i.p.; 3 times per week) displays significant anti-tumor effect. Animal Model: 6-8 weeks old Male NSG mice (bearing PANC1 or HT29 cells) Dosage: 20 mg/kg (drug stock dissolved in 1:1 Cremophor:ethanol solution) Administration: Intraperitoneally 3 times per week; 32 days (PANC1 model); 10 days (HT29 model) Result: Led to significant tumor inhibition in both PANC1 and HT29 xenografted mice. Did not visibly affect the mice body weight.

参考文献：

1. Prabhu L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8(25):39963-39977.

溶解性：

Soluble in DMSO

保存条件：

-80℃（运输条件：冰袋低温运输）

备注：

PR5-LL-CM01 是一种有效的 (PRMT5) 抑制剂 (IC50= 7.5 μM)。PR5-LL-CM01 具有抗肿瘤活性。

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.491 ml	12.453 ml	24.906 ml
5 mM	0.498 ml	2.491 ml	4.981 ml
10 mM	0.249 ml	1.245 ml	2.491 ml
50 mM	0.05 ml	0.249 ml	0.498 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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