货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T29117-1ml	10mM in DMSO	￥1000.00 T29117-1ml ￥1000.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T29117-1ml

10mM in DMSO

￥1000.00

货期：3-5天

产品描述：

NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity

靶点：

HBV

体外研究：

NVR 3-778 targets HBV core protein and inhibits viral replication.
NVR 3-778 inhibits the generation of infectious HBV DNA-containing virus particles with a mean antiviral with an EC50 of 0.40 µM in HepG2.2.15 cells.
NVR 3-778 exhibits pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication[1].
NVR 3-778 inhibits pregenomic RNA encapsidation, viral replication, and the production of HBV DNA- and HBV RNA-containing particles[1].
NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50s of 0.81 µM against HBV DNA and between 3.7µM and 4.8 µM against the production of HBV antigens and intracellular HBV RNA.
The EC50 values of NVR 3-778 are increased by 4.5-, 9.3-, and 15.8-fold in the presence of 10%, 20%, and 40% human serum, respectively.

体内研究：

NVR 3-778 (1.5 mg/kg; i.g.) displays the mean Cmax and AUC0–inf values of 0.56 µg/ml and 3.50 µg·h/ml, respectively, in dogs following oral administration. And the mean oral bioavailability is determined to be 84.6%. Animal Model: Dogs Dosage: 1.5 mg/kg (Pharmacokinetic Analysis) Administration: Oral gavage Result: The mean Cmax and AUC0–inf values are 0.56 µg/ml and 3.50 µg·h/ml and the oral bioavailability is 84.6%.

参考文献：

1. Lam AM, et al. Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus. Antimicrob Agents Chemother. 2018 Dec 21;63(1).

溶解性：

Soluble in DMSO

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.313 ml	11.564 ml	23.127 ml
5 mM	0.463 ml	2.313 ml	4.625 ml
10 mM	0.231 ml	1.156 ml	2.313 ml
50 mM	0.046 ml	0.231 ml	0.463 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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