| 产品描述： | TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1. |
| 靶点： |
Potassium Channel |
| 体外研究： |
TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state.?Overall, identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators.. |
| 参考文献： |
1. Ma Y, Luo Q, Fu J, Che Y, Guo F, Mei L, Zhang Q, Li Y, Yang H. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating. J Med Chem. 2020 Oct 8;63(19):10972-10983. doi: 10.1021/acs.jmedchem.0c00842. Epub 2020 Sep 16. PMID: 32877186. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.695 ml |
13.475 ml |
26.951 ml |
| 5 mM |
0.539 ml |
2.695 ml |
5.39 ml |
| 10 mM |
0.27 ml |
1.348 ml |
2.695 ml |
| 50 mM |
0.054 ml |
0.27 ml |
0.539 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京