货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T29191-1ml	10mM in DMSO	￥1100.00 T29191-1ml ￥1100.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T29191-1ml

10mM in DMSO

￥1100.00

货期：3-5天

产品描述：

CVT-10216是一种高选择性、可逆的ALDH-2抑制剂，IC50为29 nM

靶点：

ALDH-2:29 nM; ALDH-1:1.3 μM

体外研究：

CVT-10216 significantly reduces about 50% of aldehyde dehydrogenase (ALDH) activity in OCI-AML3 cells even in the presence of recombinant TGF-β1 or BM-MSCs, sensitizing cells to chemotherapy.

体内研究：

CVT-10216, a highly selective, reversible inhibitor of ALDH-2, exhibits both acute and prophylactic inhibitions of repeated alcohol-withdrawal-induced anxiety, which counteracts anxiogenic behavior induced by the benzodiazepine receptor inverse agonist in dose-dependently way

细胞实验：

Cell lines: OCI-AML3 cells Concentrations: 250, 500 nM, 1, 2 µM Incubation Time: 3 days Method: OCI-AML3 cells are co-cultured with MSCs (200000 cells/well density) and treated with CVT-10216 for 3 days in the presence or absence of recombinant TGF-β1 (5 ng/mL). ALDH activity is measured by ALDEFLUOR assay using flow cytometry.

动物实验：

Animal Models: FH, iP and Sprague Dawley (SD) rats Dosages: 3.75, 7.5, or 15 mg/kg Administration: i.p.

参考文献：

1. Arolfo MP, et al. Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. Alcohol Clin Exp Res. 2009 Nov;33(11):1935-44. 2. Yuan B, et al. Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway. PLoS One. 2020 Nov 30;15(11):e0242809. 3. Overstreet DH, et al. A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.

溶解性：

Soluble in DMSO

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.148 ml	10.742 ml	21.483 ml
5 mM	0.43 ml	2.148 ml	4.297 ml
10 mM	0.215 ml	1.074 ml	2.148 ml
50 mM	0.043 ml	0.215 ml	0.43 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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