| 产品描述： | BIX02188 is a potent MEK5-selective inhibitor with an IC50 of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC50 of 810 nM. |
| 靶点： |
MEK5:4.3 nM (IC50);ERK5:810 nM (IC50);CSF1R (FMS):280 nM (IC50);LCK:390 nM (IC50);KIT:550 nM (IC50);TGFβR1:1.8 μM (IC50);ABL1:2.1 μM (IC50);RPS6KA6 (RSK4):3.2 μM (IC50);RPS6KA3 (RSK2):4.1 μM (IC50);MAPK14 (p38 alpha):3.9 μM (IC50);JAK3:7.8 μM (IC50);SRC:8.9 μM (IC50) |
| 参考文献： |
1. Li L, et al. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23;370(1):159-63. 2. Badshah II, et al. Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. Front Pharmacol. 2014 Apr 21;5:71. 3. Tatake RJ, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.426 ml |
12.13 ml |
24.261 ml |
| 5 mM |
0.485 ml |
2.426 ml |
4.852 ml |
| 10 mM |
0.243 ml |
1.213 ml |
2.426 ml |
| 50 mM |
0.049 ml |
0.243 ml |
0.485 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京