货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T29315-1ml	10mM in DMSO	￥1350.00 T29315-1ml ￥1350.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T29315-1ml

10mM in DMSO

￥1350.00

货期：3-5天

产品描述：

Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy

靶点：

EC50: 12.2 µM (Ebolavirus)

体外研究：

Retro-2 (1 μM; 1-4 hours) induces autophagy in GFP-LC3-expressing HeLa cells and promoted the dramatic cytoplasmic accumulation of large autophagosomes[2].
Retro-2 (1 μM; 0.5-4 hours) treatment hows an increase over time of the abundance of LC3-II protein in cells.

Retro-2 impairs the trafficking between autophagosomes and lysosomes. Retro-2 abolishes autolysosomes formation.

Retro-2 (20 μM; pretreatment for 30 min) inhibits HeLa cell intoxication by ricin, Shiga-like toxins 1 (Stx1) and 2 (Stx2).

Retro-2 blocked invasion of cells by the intracellular parasite Leishmania, as well as replication of non-enveloped viruses, including polyoma-, papilloma-, and adeno-associated viruses.

体内研究：

Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge. Animal Model: Female Balb/c mice (Pathogen-free 6-week-old) injected with ricin (2 μg/kg) Dosage: 2 mg/kg, 10 mg/kg, 20 mg/kg, 200 mg/kg Administration: Intraperitoneal injection; daily; for 21 days Result: Protected mice against ricin challenge.

参考文献：

1. Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42.

2. Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464.

3. Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163.

溶解性：

Soluble in DMSO

保存条件：

-80℃（运输条件：冰袋低温运输）

备注：

Retro-2 是一种内体蛋白质-高尔基体逆行运输的选择性抑制剂。Retro-2 是一种埃博拉病毒 (EBOV) 感染抑制剂，在 HeLa 细胞中的EC50 为 12.2 µM。Retro-2 还可诱导细胞自噬 (autophagy)。

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.121 ml	15.605 ml	31.21 ml
5 mM	0.624 ml	3.121 ml	6.242 ml
10 mM	0.312 ml	1.561 ml	3.121 ml
50 mM	0.062 ml	0.312 ml	0.624 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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