| 产品描述： | Norbergenin is a chemical compound. It is the O-demethylated derivative of bergenin. It can be isolated from rhizomes of Bergenia stracheyi |
| 靶点： |
IL Receptor; TNF; Reactive Oxygen Species |
| 体内研究： |
Study showed that the oral administration of Bergenin (1) and Bergenin (1) at doses of 5, 10, 20, 40 and 80 mg/kg per oral dose inhibit the production of proinflammatory Th1 cytokines (IL-2,?IFN-gamma and TNF-alpha) while as potentiate anti-inflammatory Th2 cytokines (IL-4 and IL-5) in the peripheral blood of adjuvant-induced arthritic balb/c mice.?This shows the potential Th1/Th2 cytokine balancing activity of 1 and 2 which is strongly correlated with their anti-arthritic activity.?At similar dose levels, the effect of 2 was found to be more than that of 1.?The oral LD(0) for 1 and 2 was more than 2000 mg/kg body weight of the mice. |
| 参考文献： |
1. Nazir N , Koul S , Qurishi M A , et al. Immunomodulatory effect of bergenin and norbergenin against adjuvant-induced arthritis--a flow cytometric study.[J]. Journal of Ethnopharmacology, 2007, 112(2):401-405. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.182 ml |
15.911 ml |
31.822 ml |
| 5 mM |
0.636 ml |
3.182 ml |
6.364 ml |
| 10 mM |
0.318 ml |
1.591 ml |
3.182 ml |
| 50 mM |
0.064 ml |
0.318 ml |
0.636 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京