| 产品描述： | Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity |
| 靶点： |
PI3Kα：0.5 nM (IC50)；PI3Kβ：3.7 nM (IC50)；PI3Kδ：0.7 nM (IC50)；PI3Kγ：6.4 nM (IC50)；mTOR：45 nM (IC50) |
| 体内研究： |
Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model |
| 参考文献： |
1. Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30. |
| 溶解性： |
1M HCl : 100 mg/mL (208.11 mM; Need ultrasonic) |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.081 ml |
10.405 ml |
20.811 ml |
| 5 mM |
0.416 ml |
2.081 ml |
4.162 ml |
| 10 mM |
0.208 ml |
1.041 ml |
2.081 ml |
| 50 mM |
0.042 ml |
0.208 ml |
0.416 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京