| 产品描述： | GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain |
| 体内研究： |
GLN-1062 has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In animal models of drug-induced amnesia, GLN-1062 produced several fold larger cognitive improvement than the same doses of galantamine, without exhibiting any significant levels of gastrointestinal side effects that are typical for the unmodified drug and other inhibitors of cholinesterases, such as donepezil and rivastigmin. In the ferret, dramatically reduced emetic and behavioral responses were observed when GLN-1062 was administered instead of galantamine |
| 参考文献： |
1. Maelicke A, et al. Memogain is a galantamine pro-drug having dramatically reduced adverse effects and enhanced efficacy. J Mol Neurosci. 2010 Jan;40(1-2):135-7. |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.555 ml |
12.773 ml |
25.545 ml |
| 5 mM |
0.511 ml |
2.555 ml |
5.109 ml |
| 10 mM |
0.255 ml |
1.277 ml |
2.555 ml |
| 50 mM |
0.051 ml |
0.255 ml |
0.511 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京