| 产品描述： | F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM). |
| 靶点： |
5-HT Receptor |
| 体内研究： |
F-15599 exerted very potent (ID50 = 0.095 and 0.0059 mg/kg, respectively) anti-aggressive effects in male WTG rats. At 4.5-fold higher dose ranges, the anti-aggressive effects were accompanied by concomitant motor inactivity and/or reduction of social engagement. Pretreatment with WAY-100635 counteracted the behavioural effects of both agonists。 |
| 动物实验： |
F-15599 agonists were acutely administered intraperitoneally in aggressive resident male WTG rats confronting an intruder。 |
| 参考文献： |
1. Preferential in vivo action of F15599, a novel 5-HT1A receptor agonist, at postsynaptic 5-HT1A receptors[J]. British Journal of Pharmacology, 2010, 160(8):1929-1940. 2. De Boer S F , Newman-Tancredi A . Anti-aggressive effects of the selective high-efficacy ‘biased’ 5-HT1Areceptor agonists F15599 and F13714 in male WTG rats[J]. Psychopharmacology, 2016, 233(6):937-947. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.533 ml |
12.663 ml |
25.326 ml |
| 5 mM |
0.507 ml |
2.533 ml |
5.065 ml |
| 10 mM |
0.253 ml |
1.266 ml |
2.533 ml |
| 50 mM |
0.051 ml |
0.253 ml |
0.507 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京