RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.
靶点:
PDE
参考文献:
1. Alvarez et al (1995) Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3. Mol.Pharmacol. 48 616. 2. Bajpai et al (2006) AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Biol.Reprod. 74 109.