| 产品描述： | Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7 |
| 靶点： |
P2X1:2.4 μM (IC50);P2X4:2.71 μM (IC50);P2Y11:3.4 μM (IC50);P2X3:3.49 μM (IC50);P2Y4:4.89 μM (IC50);P2Y6:15.4 μM (IC50);Autophagy:140 nM (IC50);5-HT6 Receptor:1.0 μM (IC50) |
| 参考文献： |
1. Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021;S2451-9456(21)00102-1. |
| 溶解性： |
DMSO : 250 mg/mL (477.33 mM; Need ultrasonic and warming) |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.909 ml |
9.547 ml |
19.093 ml |
| 5 mM |
0.382 ml |
1.909 ml |
3.819 ml |
| 10 mM |
0.191 ml |
0.955 ml |
1.909 ml |
| 50 mM |
0.038 ml |
0.191 ml |
0.382 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京