货号	价格	上海	北京	珠海	重庆	武汉
T30005-10mg	￥2570.00 T30005-10mg ￥2570.00 2-4周	0 货期：2-4周	-	-	-	-
T30005-25mg	￥5550.00 T30005-25mg ￥5550.00 2-4周	0 货期：2-4周	-	-	-	-
T30005-50mg	￥10300.00 T30005-50mg ￥10300.00 2-4周	0 货期：2-4周	-	-	-	-

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靶点：

Ki :71 nM (D2 receptor), 1.6 nM (D3 receptor), 6220 nM (D4 receptor)

体内研究：

A-437203, a selective D3 receptor antagonist, is initially tested alone in rat forced swim test (FST). Doses of A-437203 evaluated are 0.52, 1.75, 5.24, and 17.46 μmol/kg i.p. Doses are chosen based on the selectivity of A-437203 for D3 vs D2 dopamine receptors and reports indicating that the effects of A-437203 at doses of 17.46 μmol/kg (10 mg/kg) or lower are clearly mediated by D3 but not D2 receptors, since higher doses of the compound such as 174.6 μmol/kg (100 mg/kg) are necessary to bind and block D2 receptor from the irreversible inactivation induced by the alkylating agent EEDG. ANOVA revealed no significant difference between the treatments for any of the behaviors analyzed (F4, 45=1.12, p=0.359 for immobility, F4, 45=0.188, p=0.943 for climbing, and F4, 45=1.634, p=0.182 for swimming). Based on these results, the dose of 17.46 μmol/kg i.p. of A-437203 is selected for further experiments.

参考文献：

1. Basso AM, et al. Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology. 2005 Jul;30(7):1257-68.

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.19 ml	10.952 ml	21.904 ml
5 mM	0.438 ml	2.19 ml	4.381 ml
10 mM	0.219 ml	1.095 ml	2.19 ml
50 mM	0.044 ml	0.219 ml	0.438 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

A37203