货号	规格	价格	上海	北京	珠海	重庆	武汉
T34791-5mg促销	98.90%	￥238.00 ￥190.00 T34791-5mg ￥190.00 现货	5 5	-	-	-	-
T34791-10mg促销	98.90%	￥380.00 ￥304.00 T34791-10mg ￥304.00 现货	8 8	-	-	-	-
T34791-25mg促销	98.90%	￥640.00 ￥576.00 T34791-25mg ￥576.00 现货	4 4	-	-	-	-
T34791-100mg	≥98%	￥2240.00 T34791-100mg ￥2240.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development

靶点：

Caspase;Apoptosis

体外研究：

Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses. The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells. Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml . Cell Viability Assay Cell Line: Human peripheral blood mononuclear cells Concentration: 10, 50, 100 μM Incubation Time: 48 hours Result: Inhibited T-cell proliferation in PBMC stimulated with SEB.

体内研究：

Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis. Animal Model: Male Sprague-Dawley rats (SU5416+ Z-Asp-CH2-DCB group) Dosage: 1 mg Administration: Intraperitoneal injection; every day for 3 weeks Result: The caspase 3-like activity in SU5416-treated rat lungs is significantly higher, whereas lungs from rats treated with SU5416+Z-Asp-CH2-DCB showed no increase in apoptotic activity.

参考文献：

1. Krakauer T, et al. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin Diagn Lab Immunol. 2004 May;11(3):621-4. 2. Kasahara Y, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000 Dec;106(11):1311-9. 3. Twumasi P, et al. Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures. BMC Plant Biol. 2010 Aug 6;10:162.

溶解性：

Soluble in DMSO

保存条件：

−20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.201 ml	11.007 ml	22.014 ml
5 mM	0.44 ml	2.201 ml	4.403 ml
10 mM	0.22 ml	1.101 ml	2.201 ml
50 mM	0.044 ml	0.22 ml	0.44 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

Z-Asp-CH2-DCB

(S)-3-(((benzyloxy)carbonyl)amino)-5-((2,6-dichlorobenzoyl)oxy)-4-oxopentanoic acid

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)