| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T45587-1mg买3赠1 |
99.20% | ￥710.00 |
9 | - | - | - | - |
|
T45587-5mg促销 |
99.20% | ￥1130.00 ￥904.00 |
6 | - | - | - | - |
|
T45587-10mg促销 |
99.20% | ￥2190.00 ￥1750.00 |
5 | - | - | - | - |
|
T45587-50mg促销 |
99.20% | ￥4900.00 ￥3920.00 |
2 | - | - | - | - |
|
T45587-100mg促销 |
≥98% | ￥6480.00 ￥5180.00 |
货期：2-3天 | - | - | - | - |
|
| 产品描述： | BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist. | ||||||||||||||||||||
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| 靶点： | Endothelin Receptor;EndothelinReceptor | ||||||||||||||||||||
| 体外研究： | BMS-l 82874 inhibited ET-l -stimulated inositol phosphate accumulation (KB 75 nM) and calcium mobilization (Ki = 140 nM) without suppressing the maximal responses in VSM-A10 cells. BMS-182874 competitively inhibited the binding of [125I]ET-1 to ETA receptors in rat vascular smooth muscle A10 (VSM-A10) cell membranes (Ki = 61 nM) and in CHO cells stably expressing the human ETA receptor (Ki = 48 nM), but was a weak inhibitor at ETB receptors (Ki > 50 μM) and non-ET receptors | ||||||||||||||||||||
| 体内研究： | BMS-182874 blunted the pressor response to exogenous ET-l when administered either orally (ED50 = 30 μmol/kg) or intravenously (ED50 = 24 μmol/kg) to conscious, normotensive rats. | ||||||||||||||||||||
| 参考文献： | 1. MARIA L WEBB, J. EILEEN BIRD, EDDIE C. K. LIU, PATRICIA M. ROSE, RANDY SERAFINO, PHILIP D. STEIN and SUZANNE MORELAND. BMS-182874 is a selective, nonpeptide endothelin ETA receptor antagonist. JPET 272:1124-1134, 1995. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | 2-8°C | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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