货号	规格	价格	上海	北京	珠海	重庆	武汉
T68959-5mg促销	99.50%	￥380.00 ￥304.00 T68959-5mg ￥304.00 现货	7 7	-	-	-	-
T68959-10mg促销	99.50%	￥580.00 ￥464.00 T68959-10mg ￥464.00 现货	4 4	-	-	-	-
T68959-50mg促销	99.50%	￥2000.00 ￥1600.00 T68959-50mg ￥1600.00 现货	2 2	-	-	-	-
T68959-100mg促销	≥98%	￥3390.00 ￥3050.00 T68959-100mg ￥3050.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation

靶点：

EGFR:34 nM (IC50);ErbB2:33 nM (IC50);EGFR

体外研究：

HKI-357 (0.01-10 μM) is effective in suppressing ligand-induced EGFR autophosphorylation and its downstream signaling, as determined by AKT and MAPK phosphorylation in NCI-H1975 cells. HKI-357 also is effective in suppressing EGFR autophosphorylation (measured at residue Y1068), and AKT and MAPK phosphorylation in parental NCI-H1650 cells harboring the delE746-A750 EGFR mutation. Western Blot Analysis Cell Line: NCI-H1975 bronchoalveolar cell line Concentration: 0.01, 0.01, 0.1, 1 and 10 μM Incubation Time: Result: Suppressed ligand-induced EGFR autophosphorylation and its downstream signaling AKT and MAPK phosphorylation.

参考文献：

1. Kwak EL, Sordella R, Bell DW, et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci U S A. 2005;102(21):7665-7670. doi:10.1073/pnas.0502860102

溶解性：

Soluble in DMSO

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.742 ml	8.71 ml	17.42 ml
5 mM	0.348 ml	1.742 ml	3.484 ml
10 mM	0.174 ml	0.871 ml	1.742 ml
50 mM	0.035 ml	0.174 ml	0.348 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

HKI 357

(E)-N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)