| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T70511-1mg促销 |
99.21% | ￥618.00 ￥556.00 |
5 | - | 1 | - | - |
|
T70511-5mg促销 |
99.21% | ￥1760.00 ￥1580.00 |
5 | - | - | - | - |
|
T70511-10mg促销 |
99.21% | ￥2880.00 ￥2590.00 |
6 | - | - | - | - |
|
| 产品描述： | L-AP4 (L-APB) 是一种有效的、代谢型谷氨酸受体 (mGluR) 的特异性激动剂，其对 mGlu4, mGlu8, mGlu6 和 mGlu7 受体的 EC50 值分别为 0.13, 0.29, 1.0, 249 μM。 | ||||||||||||||||||||
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| 靶点： | mGlu4 0.13 μM (EC50); mGlu8 0.29 μM (EC50); mGlu6 1.0 μM (EC50); mGlu7 249 μM (EC50) | ||||||||||||||||||||
| 体内研究： | L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction. Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats. Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion. |
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| 参考文献： | 1. Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. 2. Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6. |
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| 保存条件： | 避光,-20℃,干燥 | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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