货号	规格	价格	上海	北京	珠海	重庆	武汉
T78470-5mg买3赠1	99.10%	￥199.00 T78470-5mg ￥199.00 现货（买3赠1）	8 8	-	-	-	-
T78470-25mg买3赠1	99.10%	￥390.00 T78470-25mg ￥390.00 现货（买3赠1）	13 >10	-	-	-	-
T78470-100mg买3赠1	99.10%	￥760.00 T78470-100mg ￥760.00 现货（买3赠1）	6 6	-	-	-	-

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产品描述：

SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis

靶点：

NF-κB;MMP-9;p38 MAP kinase;NF-κB

体外研究：

SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines. SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line. SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation. Western Blot Analysis Cell Line: HT1080 human fibrosarcoma cells Concentration: 0, 1, 5, 10, 15, 20, and 25 μM Incubation Time: 24 hours Result: Greatly inhibited TNF-α (20 ng/mL)-induced MMP-9 upregulation in a concentration-dependent manner.

参考文献：

1. Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54(10):1458-67. 2. Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336(2):716-22.

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.042 ml	15.212 ml	30.424 ml
5 mM	0.608 ml	3.042 ml	6.085 ml
10 mM	0.304 ml	1.521 ml	3.042 ml
50 mM	0.061 ml	0.304 ml	0.608 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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SM-7368

3-Chloro-4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)