| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T78709-1mg促销 |
≥95% | ￥500.00 ￥450.00 |
4 | - | - | - | - |
|
T78709-5mg促销 |
≥95% | ￥1500.00 ￥1350.00 |
1 | 2 | 2 | 2 | - |
|
T78709-10mg促销 |
≥95% | ￥2400.00 ￥2160.00 |
9 | 1 | - | - | - |
|
T78709-25mg促销 |
≥95% | ￥5000.00 ￥4500.00 |
1 | - | - | - | - |
|
T78709-50mg促销 |
≥95% | ￥7000.00 ￥6300.00 |
1 | - | - | - | - |
|
T78709-100mg促销 |
≥95% | ￥10000.00 ￥9000.00 |
1 | - | - | - | - |
|
| 靶点： | Ki: 170 μM (Human GGT) | ||||||||||||||||||||
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| 体内研究： | GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats. GGsTop also reduces 4-HNE and TNF-α production, and decreases hepatic necrosis in rats. |
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| 参考文献： | 1. Han L, et al. Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase. Biochemistry. 2007 Feb 6;46(5):1432-47. 2. Kamiyama A, et al. Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity. Bioorg Med Chem. 2016 Nov 1;24(21):5340-5352. 3. Tamura K, et al. GGsTop, a novel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats. Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G305-12. |
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| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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北京