货号	规格	价格	上海	北京	珠海	重庆	武汉
T80475-5mg买3赠1	99.40%	￥935.00 T80475-5mg ￥935.00 现货（买3赠1）	6 6	-	-	-	-
T80475-10mg促销	99.40%	￥1530.00 ￥1220.00 T80475-10mg ￥1220.00 现货	6 6	-	-	-	-
T80475-25mg促销	99.40%	￥2970.00 ￥2370.00 T80475-25mg ￥2370.00 现货	5 5	-	-	-	-
T80475-100mg促销	≥99%	￥7680.00 ￥6140.00 T80475-100mg ￥6140.00 2-3天	0 货期：2-3天	-	-	-	-

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产品描述：

PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively

靶点：

IC50: 23.1 µM (NGF-p75NTR, PC12 cells), 1.8 µM (NGF-p75NTR, PC12nnr5 cells)

体外研究：

PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR. PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR. PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM. PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 µM and 1.8 µM in PC12 cells and PC12nnr5 cells, respectively.

参考文献：

1. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11.

溶解性：

soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.76 ml	13.799 ml	27.598 ml
5 mM	0.552 ml	2.76 ml	5.52 ml
10 mM	0.276 ml	1.38 ml	2.76 ml
50 mM	0.055 ml	0.276 ml	0.552 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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