| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
T83647-5mg促销 |
≥95% | ￥842.00 ￥756.00 |
10 | - | - | - | - |
|
T83647-10mg促销 |
≥95% | ￥1640.00 ￥1480.00 |
10 | - | - | - | - |
|
T83647-25mg促销 |
≥95% | ￥2710.00 ￥2440.00 |
6 | - | - | - | - |
|
T83647-50mg促销 |
≥95% | ￥4620.00 ￥4150.00 |
4 | - | - | - | - |
|
T83647-100mg促销 |
≥95% | ￥9190.00 ￥8270.00 |
1 | - | - | - | - |
|
| 产品描述： | RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research | ||||||||||||||||||||
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| 靶点： | 5-HT4 Receptor:8.7 (pKi);5-HTReceptor | ||||||||||||||||||||
| 体外研究： | RS 67333 hydrochloride does exhibit affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT. | ||||||||||||||||||||
| 参考文献： | 1. R M Eglen, et al. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br J Pharmacol. 1995 Aug;115(8):1387-92. | ||||||||||||||||||||
| 溶解性： | Soluble in DMSO | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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