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CCR2 antagonist 4 hydrochloride

    
≥99%

CCR2 antagonist 4 hydrochloride

源叶(MedMol)
T84618 一键复制产品信息
1313730-14-1
C21H22Cl2F3N3O2
476.32
CCR2 antagonist 4 hydrochloride;Teijin compound 1 hydrochloride
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
T84618-5mg促销
≥99%

¥764.00 ¥686.00

4 - - - -
T84618-10mg促销
≥99%

¥1350.00 ¥1210.00

5 - - - -
T84618-25mg促销
≥99%

¥2690.00 ¥2420.00

4 - - - -
T84618-50mg促销
≥99%

¥4850.00 ¥4370.00

4 - - - -
T84618-100mg促销
≥99%

¥8090.00 ¥7280.00

3 - - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品
产品描述:

CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) 是一种高效、特异的 CCR2 拮抗剂,对 CCR2b 的 IC50 值为 180 nM。CCR2 antagonist 4 hydrochloride 对 MCP-1 诱导的趋化作用有较强的抑制作用,其 IC50 为 24 nM。

靶点: CCR2b:180 nM (IC50)
体外研究: Ile263 and Thr292 in CCR2 contribute significantly to binding of CCR2 antagonist 4 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4 hydrochloride, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride.
体内研究: In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta.
参考文献: 1. Moree WJ, et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1869-73.

2. Hall SE, et al. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Mol Pharmacol. 2009 Jun;75(6):1325-36.

3. Calin M, et al. VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes. Eur J Pharm Biopharm. 2015 Jan;89:18-29.
溶解性: soluble  in  DMSO
保存条件: 2-8℃;干燥
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.099 ml 10.497 ml 20.994 ml
5 mM 0.42 ml 2.099 ml 4.199 ml
10 mM 0.21 ml 1.05 ml 2.099 ml
50 mM 0.042 ml 0.21 ml 0.42 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

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