品牌：源叶(MedMol)

产品编号：T87782 一键复制产品信息

CAS号：909725-61-7

分子式：C₁₆H₂₇N₂O₄P

分子量：342.370341

别名：W146HYDRATE;[(3R)-3-aMino-4-[(3-hexylphenyl)aMino]-4-oxobutyl]-phosphonic acid;[(3R)-3-aMino-4-[(3-hexylphenyl)aMino]-4-oxobutyl]-phosphonic acid(CAS#:909725-61-7);ML056;R-3-amino-4-(3-hexylphenylamin;W146HYDRATE

货号	规格	价格	上海	北京	珠海	重庆	武汉
T87782-1mg	≥98%(HPLC)	￥900.00 T87782-1mg ￥900.00 现货	10 0 10	-	-	-	-
T87782-5mg	≥98%(HPLC)	￥3150.00 T87782-5mg ￥3150.00 现货	10 10	-	-	-	-
T87782-10mg	≥98%(HPLC)	￥5000.00 T87782-10mg ￥5000.00 现货	10 10	-	-	-	-
T87782-25mg	≥98%(HPLC)	￥10000.00 T87782-25mg ￥10000.00 现货	10 10	-	-	-	-

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靶点：

EC50: 398 nM (S1PR1).

体内研究：

W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 alone
The W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice.

参考文献：

1. M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2(8):434-41. Epub 2006 Jul 9.
2. Jingjing Liu, et al. 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Bioc
3. Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.921 ml	14.604 ml	29.208 ml
5 mM	0.584 ml	2.921 ml	5.842 ml
10 mM	0.292 ml	1.46 ml	2.921 ml
50 mM	0.058 ml	0.292 ml	0.584 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

W146,S1P1受体拮抗剂

[(3R)-3-aMino-4-[(3-hexylphenyl)aMino]-4-oxobutyl]-phosphonic acid

参考文献

质检证书(COA)

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)