Caspase-3 选择性抑制剂 | 活化剂 | 调节剂;Caspase-3 Selective Inhibitors | Activators | Modulators;;InformationSenkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. Senkyunolide I (SEI, SENI) up-regulates the phosphorylation ofErk1/2and inducesNrf2nuclear translocation with enhanced HO-1 and NQO1 expressions. Senkyunolide I (SEI, SENI) promotes the ratio ofBcl-2/Baxand inhibits the expressions of cleavedcaspase 3andcaspase 9.TargetsErk1 ; Erk2 ; Nrf2 ; Bcl-2/Bax ; Caspase-3 33829,