货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T88036-1ml促销	10mM in DMSO	￥720.00 ￥648.00 T88036-1ml ￥648.00 现货	9 9	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T88036-1ml促销

10mM in DMSO

￥720.00 ￥648.00

产品描述：

VEGFR2 选择性抑制剂;VEGFR2 Selective Inhibitors;;InformationCS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selectiveVEGFR-2inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such asRET (c-RET)andKit (c-Kit)with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3.TargetsVEGFR2 (Cell-free assay); RET (Cell-free assay); Kit (Cell-free assay) 40 nM; 180 nM; 500 nM

体内研究：

JNJ-38158471 (10 or 100 mg/kg; p.o.; once-daily) inhibits VEGF-induced corneal neovascularization.
JNJ-38158471 (10-200 mg/kg; p.o.) inhibits the growth of human tumor xenografts in a dose-dependent manner in both A431 and HCT116 models. JNJ-38158471 treatment is well tolerated, following continuous administration for 24 days, body weights were comparable with control animals.
JNJ-38158471 (100 mg/kg; p.o.; once-daily) treatment shows statistically signiﬁcant activity compare with vehicle treat animals. The body weights of both JNJ-38158471-treated and vehicle-treated groups were comparable at study end.

参考文献：

1. Kenneth RL, et, al. A Highly Selective, Orally Bioavailable, Vascular Endothelial Growth Factor receptor-2 Tyrosine Kinase Inhibitor Has Potent Activity in Vitro and in Vivo. Angiogenesis. 2009; 12(3): 287-96.

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.741 ml	13.707 ml	27.413 ml
5 mM	0.548 ml	2.741 ml	5.483 ml
10 mM	0.274 ml	1.371 ml	2.741 ml
50 mM	0.055 ml	0.274 ml	0.548 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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