货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T88366-1ml促销	10mM in DMSO	￥890.00 ￥800.00 T88366-1ml ￥800.00 现货	7 7	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T88366-1ml促销

10mM in DMSO

￥890.00 ￥800.00

产品描述：

DNA/RNA 合成抑制剂;DNA/RNA Synthesis Inhibitors;;InformationHalofuginone Halofuginone (RU-19110) is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.TargetsSmad3 ; prolyl-tRNA synthetase (Cell-free assay) ; 18.3nM(Ki)In vitroIn mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells.In vivoHalofuginone clearly extends the survival times of the parasite-infected mice. Oral treatment with halofuginone at doses of 0.2 and 1 mg/kg has an apparent curative effect for the infected mice.The subcutaneous administration of 0.2 mg of halofuginone per kg likewise extends the survival times of the infected mice, but none of the mice is cured. The mice in the 5-mg/kg dose groups die before the completion of treatment with the drug either orally or subcutaneously. Subcutaneous treatment with halofuginone appears to be more toxic to mice than oral treatment.Cell Research(from reference)Cell lines：primary murine CD4+ CD25− T cells/MEFs Concentrations：5-20nM Incubation Time：4 or 24hrs

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.411 ml	12.057 ml	24.115 ml
5 mM	0.482 ml	2.411 ml	4.823 ml
10 mM	0.241 ml	1.206 ml	2.411 ml
50 mM	0.048 ml	0.241 ml	0.482 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

常山酮

Halofuginone

参考文献

质检证书(COA)

如何获取质检证书(COA)?

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)