货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
T88406-1ml	10mM in DMSO	￥1180.00 T88406-1ml ￥1180.00 现货	7 7	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

T88406-1ml

10mM in DMSO

￥1180.00

产品描述：

HDAC6 选择性抑制剂;HDAC6 Selective Inhibitors;;InformationACY-738 inhibitsHDAC6with low nanomolar potency (IC50=1.7 nM) and a selectivity of 60- to 1500-fold over class I HDACs.TargetsHDAC6 (Cell-free) 1.7 nMIn vivoACY-738 induces dramatic increases in α-tubulin acetylation in brain and stimulate mouse exploratory behaviors in novel, but not familiar environments. ACY-738 has the antidepressant-like properties. Elimination of ACY-738 from plasma is rapid, with plasmatic half-life of 12\u2009min and concentration below 10\u2009ng/ml after 2\u2009h. ACY-738 rapidly distributes to the brain leading to a total drug exposure in CNS comparable to that of peripheral tissues. ACY-738 decreases several characteristics of SLE (Systemic lupus erythematosus) in NZB/W mice by dictating B cell development in the bone marrow. ACY-738 treatment increases the percentage of B cells in early developmental stages, while decreasing the percentage of cells in late pre-B cell fraction F. ACY-738 regulation of BM B cell development could be due to regulation developmental checkpoints known to be dysfunctional during SLE.Cell Research(from reference)Cell lines：Undifferentiated RN46A-B14 cells Concentrations：2.5\u2009μM Incubation Time：4 h

保存条件：

-80℃（运输条件：冰袋低温运输）

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.7 ml	18.499 ml	36.997 ml
5 mM	0.74 ml	3.7 ml	7.399 ml
10 mM	0.37 ml	1.85 ml	3.7 ml
50 mM	0.074 ml	0.37 ml	0.74 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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